目的 研究多枝霧水葛不同提取物的抗炎鎮(zhèn)痛作用。方法 采用二甲苯致小鼠耳腫脹、醋酸致小鼠扭體反應(yīng)和小鼠熱板法觀察多枝霧水葛灌胃、外搽使用以及不同提取部位的抗炎、鎮(zhèn)痛作用。結(jié)果 多枝霧水葛外搽使用的抗炎鎮(zhèn)痛效果不明顯，灌胃給藥具有較強的抗炎鎮(zhèn)痛作用，能顯著減少醋酸所致的小鼠扭體次數(shù)和抑制二甲苯所致的小鼠耳廓腫脹，且其水提物比醇提物的作用更強。對多枝霧水葛水提取物的活性部位研究表明，多枝霧水葛的氯仿部位和水部位都具有較好的鎮(zhèn)痛效果，抗炎的有效部位則是氯仿部位和正丁醇部位。結(jié)論 多枝霧水葛水提取物灌胃給藥具有抗炎鎮(zhèn)痛作用，其有效部位是氯仿部位、正丁醇部位和水提取部位。

Objective To study the anti-inflammatory and analgesic effects of different extracts from Pouzolzia zeylanica var. microphylla. Methods The xylene-induced ear edema of mice, acetic acid-induced writhing of mice, and hot-plate procedure in mice were used. The anti-inflammatory and analgesic effects of P. zeylanica var. microphylla by ig administration and external use were observed, and the effects of different extract fractions from P. zeylanica var. microphylla were studied. Results There were no obvious anti-inflammatory and analgesic effects of P. zeylanica var. microphylla by external use, while ig administration had stronger analgesia by significantly reducing the number of body torsion and inhibiting xylene-induced ear edema of mice. The water extracts had much better effect than the ethanol extracts. According to the study on the active fractions of water extract from P. zeylanica var. microphylla, it showed that both chloroform and water fractions had better analgesic effects, while the portions of chloroform and n-butanol had better anti-inflammatory activity. Conclusion The water extracts from P. zeylanica var. microphylla by ig administration has anti-inflammatory and analgesic effects and the main active fractions are chloroform, n-butanol, and water fractions.