目的 合成地拉羅司并對工藝進行優(yōu)化研究。方法 以水楊酸為原料，經與二氯亞砜氯化、水楊酰胺脫水環(huán)合和對羧基苯肼開環(huán)重排3步得到口服鐵螯合劑地拉羅司。結果 地拉羅司合成總收率為59.36%。結論 對工藝進行了改進，提高了地拉羅司合成收率。

Objective To synthesize deferasirox and optimize its synthetic technology. Methods Deferasirox, an orally available iron chelator, was synthesized by cyclization of salicylaldehyde chloride with salicylamide and 4-hydrazinobenzoic acid, in which salicylaldehyde chloride was prepared with salicylic acid and thionyl chloride under normal temperature. Results Deferasirox was prepared with an overall yield of 59.36%. Conclusion The improved technology could increase the yield of deferasirox.

2012年度大學生科技創(chuàng)新項目（2012DKC14）