目的 合成托吡酯并對(duì)工藝進(jìn)行研究。方法 以D-果糖為起始原料，在濃硫酸的催化下，與丙酮縮合生成雙丙酮果糖，再同氯磺酸異氰酸酯反應(yīng)采用“一鍋法”制備，得到托吡酯。結(jié)果 本工藝總收率為43.3%。結(jié)論 工藝改進(jìn)后，簡(jiǎn)化了操作過(guò)程，提高了托吡酯的收率。

Objective To synthesize topiramate and research the synthetic process. Methods Catalyzed by concentrated sulfuric acid, D-fructopyranose was used as the initial raw material, then condensation of D-fructopyranose with acetone to synthesize 2,3,4,5-bis-O-(1-methylethylidene)-D-fructopyranose. The topiramate was produced by reaction between 2,3,4,5-bis-O-(1- methylethylidene)-D-fructopyranose and chlorosulfonyl isocyanate via one pot method. Results The total yield by the synthetic process was 43.3%. Conclusion After the process improvement, the operating process is simplified and the yield of topiramate is improved.