目的 探討龍甲血脈通膠囊對大鼠心肌缺血及心肌缺血再灌注損傷的保護(hù)作用。方法 采用垂體后葉素和異丙腎上腺素誘導(dǎo)的大鼠心肌缺血模型，考察龍甲血脈通膠囊對心肌缺血作用的保護(hù)；采用手術(shù)致大鼠心肌缺血再灌注損傷模型，考察龍甲血脈通膠囊的對心肌缺血再灌注損傷的保護(hù)作用。結(jié)果 龍甲血脈通膠囊（1.60、0.80、0.40 g/kg）能夠顯著降低垂體后葉素誘導(dǎo)的心肌缺血大鼠15 s、30 s時T波高度；能夠顯著降低異丙腎上腺素誘導(dǎo)的大鼠心肌缺血5、10、20、30 min S-T段偏移高度。龍甲血脈通膠囊（1.60、0.80、0.40 g/kg）能夠顯著降低血清丙二醛（MDA）水平，顯著升高超氧化物歧化酶（SOD）水平，顯著降低缺血再灌注損傷大鼠的心肌梗死區(qū)面積占缺血區(qū)面積的比例。結(jié)論 龍甲血脈通膠囊具有保護(hù)心肌缺血及抗心肌缺血再灌注損傷的作用。

Objective To observe protective effects of Longjia Xuemaitong Capslue on myocardial ischemia and cardiac reperfusion injury. Methods Using the myocardial ischemia model of rats induced by pituitrin and isoproterenol, the effects of Longjia Xuemaitong Capslue on myocardial ischemia were investigated. Moreover, using the myocardial ischemia-eperfusion injury model of rats induced by operation, the protective effects of Longjia Xuemaitong Capslue on myocardial ischemia-reperfusion injury were observed. Results At the doses of 1.60, 0.80, 0.40 g/kg, Longjia Xuemaitong Capslue could significantly reduce the T wave height at 15 and 30 s in the ischemia rats induced by pituitrin as well as the offset height of S-T segment at 5, 10, 20, and 30 min in ischemia rats induced by isoproterenol. Longjia Xuemaitong Capslue at the doses of 1.60, 0.80, and 0.40 g/kg could significantly decrease the malondialdehyde (MDA) level in serum, increase the superoxide dismutase (SOD) level, and obviously decrease the percentage that the infarct area accounted for the ischemic area in the myocardial ischemia-reperfusion injury of rats. Conclusion Longjia Xuemaitong Capslue could protect the myocardial ischemia and myocardial ischemia-reperfusion injury.