淫羊藿為我國(guó)傳統(tǒng)中藥，具有補(bǔ)腎陽、強(qiáng)筋骨、祛風(fēng)濕的功效。淫羊藿中主要活性成分是以淫羊藿苷為代表的黃酮苷類化合物。近年來研究發(fā)現(xiàn)淫羊藿給藥后發(fā)揮功效的物質(zhì)基礎(chǔ)主要為其活性成分的代謝產(chǎn)物。綜述近年來國(guó)內(nèi)外對(duì)淫羊藿中活性成分的代謝產(chǎn)物的研究方法及代謝產(chǎn)物研究進(jìn)展，對(duì)進(jìn)一步闡明淫羊藿藥材的作用機(jī)制、研制新藥具有直接指導(dǎo)意義。

Epimedii Herba is one of the traditional Chinese materia medica with the function of invigorating kidney, strengthening yang, and eliminating wind and dampness. Flavonoid glycosides of icariin as the representative, are the main active chemical components in Epimedii Herba. Recent studies have found that the material basis of these compounds may be their metabolites in vivo. The paper reviews the research progress in the metabolites of the active constituents in Epimedii Herba, which could provide the effective guidance for further understanding their mechanism and the development of the related drugs.

國(guó)家重大新藥創(chuàng)制科技重大專項(xiàng)（2009ZX09102）