鼻腔與腦在解剖生理上的獨特聯(lián)系使得鼻腔給藥作為腦內(nèi)遞藥途徑成為可能。鼻腔給藥作為腦靶向的途徑之一，可有效地使通過其他給藥途徑不易透過血腦屏障的藥物繞過血腦屏障到達(dá)腦部，為中樞神經(jīng)系統(tǒng)疾病的治療提供了一種極有發(fā)展前景的腦內(nèi)遞藥途徑。就鼻腔給藥腦靶向的依據(jù)、影響因素、評價方法、劑型等方面對經(jīng)鼻腦靶向遞藥系統(tǒng)的研究現(xiàn)狀進(jìn)行總結(jié)。

The unique anatomy and physiology links between nose and brain make it possible for intranasal drug delivery as delivery pathway to brain. It was suggested that drug nasal delivery system is prospecting in providing a potential treatment against central nervous system diseases, which could effectively make drugs hard to pass through blood brain barrier (BBB) to brain. Status of study on the bases of nasal delivery system, influencing factors, evaluation methods, and dosage forms were reviewed to summarize the process of intranasal drug delivery for brain targeting.