近些年來，二肽基肽酶Ⅳ（dipeptidyl peptidase IV，DPP-IV）抑制劑在治療2型糖尿病的藥物中異軍突起，DPP-IV是一種2型多功能跨膜細胞表面糖基化蛋白，在臨床治療和臨床試驗中，發(fā)現(xiàn)了很多DPP-IV抑制劑潛在的藥理作用。通過對國內外相關文獻的檢索，對DPP-IV抑制劑包括降糖、保護心臟、抗炎等藥理作用進行了綜述。

In recent years, the dipeptidyl peptidase IV (DPP-IV) inhibitors have been used for the treatment of type 2 diabetes. DPP-IV inhibitor is a kind of type 2 multifunctional transmembrane cell surface glycosylation protein, and lots of the potential pharmacological effects of DPP-IV inhibitors have been reported in the clinical treatment and trials. In this paper, the major pharmacological effects of DPP-IV inhibitors including hypoglycemic, cardiovascular system preservation, anti-inflammatory actions, etc. have been summarized through searching the related references at home and abroad.

遼寧省重點大學科學研究項目（L2010433）