2型糖尿病是一種慢性代謝障礙性疾病，呈進(jìn)行性發(fā)展，很難治愈，占糖尿病的90%以上。目前治療該病的藥物有很多，包括傳統(tǒng)藥物如磺脲類、格列奈類、噻唑烷二酮類、雙胍類和α-葡萄糖苷酶抑制劑，以及近些年出現(xiàn)的新作用機(jī)制藥物如GLP-1受體激動(dòng)劑、DDP-IV抑制劑和SGLT2抑制劑。對(duì)上述各類藥物的研究情況進(jìn)行綜述。

Type 2 diabetes is a kind of chronic metabolic disorders and progressive diseases difficult to cure, which is accounting for more than 90% of the diabetes. Currently, there are a lot of drugs for the treatment of type 2 diabetes, including the traditional drugs such as sulfonylureas, glinides, thiazolidinediones, biguanides, and α-glucosidase inhibitor, and drugs with new mechanism developed in recent years, such as GLP-1 receptor agonist, DDP-IV inhibitor, and SGLT2 inhibitors. This article reviewed the research and development of the above types of drugs.