[關(guān)鍵詞]
[摘要]
目的 制備依托泊苷長(zhǎng)循環(huán)亞微乳，并對(duì)其進(jìn)行理化性質(zhì)研究。方法 在依托泊苷亞微乳處方的基礎(chǔ)上，通過(guò)考察乳粒表面固有水化層厚度與聚乙二醇2000–二硬脂酰磷脂酰乙醇胺（PEG 2000-DSPE）用量的關(guān)系，確定PEG 2000-DSPE用量，從而確定了依托泊苷長(zhǎng)循環(huán)亞微乳的處方和制備工藝，并進(jìn)行了理化性質(zhì)研究。結(jié)果 依托泊苷長(zhǎng)循環(huán)亞微乳的濃度為0.8 mg/mL，平均粒徑為（185.4±5.7）nm，Zeta電位為（?51.6±0.8）mV，藥物包封率為97.52%。結(jié)論 得到了包封率在95%以上的依托泊苷濃度為0.8 mg/mL的依托泊苷長(zhǎng)循環(huán)亞微乳的處方和制備工藝。
[Key word]
[Abstract]
Objective To prepare etoposide long circulating submicroemulsion (ELCSE) and to study its physico-chemical properties. Methods Based on the formulation of etoposide submicroemulsion, the quantity of PEG 2000-DSPE was decided by studying the relationship between the fixed aqueous layer thickness (FALT) of emulsion drop surface and the quantity of PEG 2000-DSPE. Then the ELCSE formulation and the preparing technique were decided, and the physico-chemical properties were studied. Results The concentration of etoposide was 0.8 mg/mL. The mean particle size, Zeta potential, and encapsulation efficiency of ELCSE were (185.4 ± 5.7) nm, (?51.6 ± 0.8) mV, and 97.52%, respectively. Conclusion The ELCSE formulation and preparing technique with etoposide concentration of 0.8 mg/mL and encapsulation efficiency over 95% are obtained.
[中圖分類號(hào)]
[基金項(xiàng)目]
國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973計(jì)劃）資助項(xiàng)目（2010CB735602，2012CB724002）
