目的 研究生脈散超微粉的顯微特征和溶出度差異，為生脈超微粉應(yīng)用提供實驗依據(jù)。方法 采用光學顯微鏡觀察顆粒顯微結(jié)構(gòu)；電鏡掃描觀察微觀形貌；以五味子甲素和五味子乙素為指標，采用HPLC法測定生脈散細粉和超微粉在不同時間溶出的量，計算累積溶出度。結(jié)果 生脈散經(jīng)超微粉碎后，基本無完整細胞存在，粒度均勻；生脈散超微粉中五味子甲素和五味子乙素溶出速率高于細粉，但是180 min后累積溶出量沒有明顯差異。結(jié)論 超微粉碎可使生脈散顯微特征變化明顯，化學成分五味子甲素和五味子乙素溶出速率加快。

Objective To study the micro-characteristic and dissolution of ultra-micro powder in Shengmai Powder, and to provide experimental foundation for the application of ultra-micro powder in Shengmai Powder. Methods The microstructure was observed by light microscope and the micro shape was observed by .electron microscope scanning. The dissolutions of Shengmai Powder and ultra-micro powder in Shengmai Powder at different time were determined by HPLC using schizandrins A and B as indexes. Results Compared with the common powder, the cellules of ultra-micro powder were pulverized, and the particles were tiny without intact cells and uniform. The cumulative dissolution rates of schizandrins A and B in ultra-micro powder were higher than those in the traditional common powder, but there was no significant difference after 180 min. Conclusion The micro-characteristic of ultra-micro powder in Shengmai Powder is obviously changed after ultrafine grinding, and the dissolution velocity of schizandrins A and B increases.

國家重點基礎(chǔ)研究發(fā)展計劃（973計劃）項目（2010CB735604）