目的 觀察奧美拉唑注射液預防腦出血合并上消化道出血的臨床療效。方法 腦出血患者37例，隨機分為治療組（17例）和對照組（18例），對照組患者給予常規(guī)藥物降低顱壓，控制腦水腫和血壓，維持電解質平衡；應用止血劑、抗生素等對癥治療；治療組在對照組基礎上應用奧美拉唑40 mg靜推，2次/d，共14 d，治療結束后評價兩組并發(fā)上消化道出血的發(fā)生率以及患者的急性期病死率。結果 治療組和對照組并發(fā)上消化道出血的發(fā)生率分別為5.88%、33.33%，兩組比較有統(tǒng)計學差異（P＜0.01），急性期病死率分別為11.76%、44.44%，兩組比較有統(tǒng)計學差異（P＜0.01）。結論 奧美拉唑注射液不僅可以大大降低腦出血并發(fā)上消化道出血的發(fā)生率，而且可以明顯降低患者急性期的死亡率。

Objective To observe the clinical effect of Omeprazole Injection (OI) on preventing upper gastrointestinal hemorrhage in patients with cerebral hemorrhage. Methods The patients with cerebral hemorrhage were randomly divided into treatment group (17 cases) and control group (18 cases). The patients in the control group were administered with conventional drugs to reduce intracranial pressure, control encephaledema and blood pressure, and maintain electrolyte balance. At the same time, patients were administered with hemostatic agents and antibiotics. The patients in the treatment group were injected with OI on the basis of the control group, twice daily, for 14 d. The incidence of upper gastrointestinal hemorrhage and acute mortality was evaluated in the end of the treatment. Results The incidence of upper gastrointestinal hemorrhage both in the treatment and control groups was 5.88% and 33.33%, respectively, with the significant difference (P < 0.01). The acute mortality in two groups was 11.76% and 44.44%, respectively, with the significant difference (P < 0.01). Conclusion OI could not only greatly reduce the incidence of upper gastrointestinal hemorrhage in patients with cerebral hemorrhage, but also could significantly reduce the acute mortality.