目的 觀察康復(fù)新液聯(lián)合慶大霉素直腸滴注治療潰瘍性結(jié)腸炎的療效。方法 將92例潰瘍性結(jié)腸炎患者隨機(jī)分為兩組，治療組給予康復(fù)新液50 mL加慶大霉素8×104 U加入0.9%氯化鈉液50 mL充分混合后，加溫至38 ℃左右，緩慢直腸滴入，每日早晚各一次，15 d一個(gè)療程，間隔5 d行下一療程，連用2個(gè)療程，病情穩(wěn)定后口服美沙拉嗪緩釋片1 g/次，1次/d，鞏固療效。對照組口服美沙拉嗪緩釋片1 g/次，3次/d，病情穩(wěn)定后逐漸減量至治療組劑量鞏固治療。觀察治療過程中兩組患者不良反應(yīng)發(fā)生情況，治療結(jié)束后評(píng)價(jià)兩組的治療療效及總有效率。結(jié)果 對照組總有效率67.4%，治療組總有效率80.4%，治療組明顯優(yōu)于對照組，兩組差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。兩組患者均有輕微胃部不適、惡心癥狀發(fā)生，治療組3例，對照組2例，均未影響治療。結(jié)論 康復(fù)新液聯(lián)合慶大霉素直腸滴注治療潰瘍性結(jié)腸炎有較好的療效，且不良反應(yīng)輕微，值得臨床推廣。

Objective To observe the clinical effect of Kangfuxin Liquid (KL) combined with gentamicin by rectum drop on the treatment of ulcerative colitis. Methods Patients with ulcerative colitis (92 cases) were randomly divided into two groups. In the treatment group, KL(50 mL) and gentamicin (8×104 U) were added into 0.9% sodium chloride liquid (50 mL), mixed thoroughly, and heated up to about 38 ℃. The KL combined with gentamicin was dropped into rectum slowly, twice daily, each time in the morning and evening, 15 d as one course, and after 5 d broke, the next course began, for continuous two courses. When the condition of patients was stable, they took Mesalazine Sustained-release Tablets (1 g) orally once daily to enhance the curative effect. In control group, patients took Mesalazine Sustained-release Tablets orally, 1 g once for three times a day. When the condition of patients was stable, the dosage was reduced to that in the treatment group to consolidate the curative effect. The adverse reactions of patients were observed during the treatment, and the therapeutic efficacy and total efficiency were evaluated in the end of the treatment. Results The efficiency of control and treatment groups was 67.4% and 80.4%, respectively, with the significant difference between the two groups (P < 0.05). Patients in both groups had mild stomach upset and nausea symptoms (3 cases in the treatment group and 2 cases in the control group), which did not affect on the treatment efficacy. Conclusion: KL combined with gentamicin has a better therapeutic effect on ulcerative colitis with less adverse reactions, which could be worth of spreading in clinic.