目的 探討利奈唑胺所致不良反應(yīng)的特點及相關(guān)因素，為臨床合理用藥提供參考。方法 檢索2000年1月—2012年11月國內(nèi)醫(yī)藥期刊報道的44例利奈唑胺致不良反應(yīng)案例，并進行統(tǒng)計、分析。結(jié)果 利奈唑胺所致不良反應(yīng)主要體現(xiàn)在血液、心血管及消化系統(tǒng)等，并且老年患者更易發(fā)生。結(jié)論 臨床應(yīng)加強對利奈唑胺的合理使用，盡量避免或減少其所致不良反應(yīng)的發(fā)生。

Objective To study the characteristics and related factors of the adverse drug reaction (ADR) induced by linezolid, so as to provide the references for the rational use of drugs in clinic. Methods Forty-four cases of ADR induced by linezolid, which were reported in domestic medical academic journals from January 2000 to November 2012, were statistically analyzed. Results The ADR induced by linezolid occured mainly in blood system, cardiovascular system, digestive system, and so on, at the same time, most of cases occurred in senile patients. Conclusion The rational use of linezolid should be emphasized to avoid or reduce the incidence of ADR.