膿毒癥是指由感染引起的全身性炎癥反應(yīng)，是嚴(yán)重感染、重度創(chuàng)傷或燒傷、外科手術(shù)后常見的并發(fā)癥，患病率高、病死率高，沒有特效藥物，是世界性醫(yī)學(xué)難題。近年來的臨床和實(shí)驗(yàn)研究發(fā)現(xiàn)，多個(gè)中藥單體成分在治療膿毒癥方面有一定的效果。將治療膿毒癥的有效成分根據(jù)其化學(xué)結(jié)構(gòu)進(jìn)行分類，綜述近年來中藥有效成分在治療膿毒癥方面的研究進(jìn)展，為進(jìn)一步研究與開發(fā)治療膿毒癥的新藥提供思路和參考。

Sepsis is the systemic inflammatory response syndrome caused by infection, which is common complications after serious infection, sever trauma or burn, and surgery. Becarse of the high prevalence and mortality but no effective drugs, sepsis becomes the crux of the worldwide medical problem. In recent years, the clinical and experimental studies have found that a variety of monomer constituents in Chinese materia medica have the certain effects in the treatment of sepsis. This paper reviews the research advances in study on the active constituents from Chinese materia medica for treating sepsis according to their chemical structures, and it could provide the ideas and references for the further research and development in Chinese materia medica for the treatment of sepsis.

天津市自然科學(xué)基金資助項(xiàng)目（10JCZDC18900）