[關鍵詞]
[摘要]
由于血腦屏障的存在，血液中的藥物難以進入中樞神經(jīng)系統(tǒng)。近些年研究表明，經(jīng)鼻腔給藥后，藥物可以繞過血腦屏障直接進入腦部，而且其對機體的損傷和副作用都較小，因此經(jīng)鼻腦靶向給藥系統(tǒng)不斷受到更多人的關注。首先探討了藥物經(jīng)鼻入腦的通路及機制，并針對鼻腔給藥的不同影響因素提出了相應的優(yōu)化方案，還介紹了腦靶向性的評價方法，為進一步研究鼻腦靶向制劑提供了參考。
[Key word]
[Abstract]
The blood-brain barrier (BBB) limits the distribution of systemically administered therapeutics to the central nervous system (CNS). Recent researches found that intranasal administration was a non-invasive method of drug delivery which might bypass the BBB to allow therapeutic substances direct access to the CNS with little body injury and side effects. So the intranasal delivery to CNS has attracted people’s attention. This review focuses on the current understanding of the mechanisms and potential pathways underlying the intranasal delivery to the CNS, puts forward several methods to optimize the system considering the factors, and introduces the evaluation methods of brain targeting to propel the research of the system.
[中圖分類號]
[基金項目]
中藥制藥過程新技術國家重點實驗室開放基金課題（SKL2010M0302）；北京中醫(yī)藥大學復方中藥制藥研究創(chuàng)新團隊（2011-CXTD-13）；北京中醫(yī)藥大學自主課題項目（2011-JYBZZ-JS048，2011JYB22XS-063）
