目的 探討消退素D1的抗三叉神經(jīng)痛作用。方法 健康SD大鼠按體質(zhì)量隨機(jī)分為模型組、消退素D1（30、90、270 μg/kg）組和苯妥英鈉陽性對(duì)照組，采用腦內(nèi)注射青霉素G鉀致大鼠三叉神經(jīng)痛模型，考察消退素D1抗三叉神經(jīng)痛作用。健康SD大鼠按體質(zhì)量隨機(jī)分為假手術(shù)組、模型組、消退素D1（30、90、270 μg/kg）組和苯妥英鈉陽性對(duì)照組，采用慢性壓迫性損傷眶下神經(jīng)致大鼠三叉神經(jīng)痛模型，考察消退素D1抗三叉神經(jīng)痛作用。結(jié)果 消退素D1（30、90、270 μg/kg）能夠顯著延長大鼠出現(xiàn)疼痛反應(yīng)（發(fā)生尖叫、甩頭和后肢抓撓面部）的潛伏期，減少大鼠60 min內(nèi)的疼痛反應(yīng)時(shí)間；能夠顯著升高慢性壓迫性損傷大鼠眶下神經(jīng)致三叉神經(jīng)痛模型大鼠的疼痛反應(yīng)閾值。結(jié)論 消退素D1具有抗三叉神經(jīng)痛作用。

Objective To observe the effect of resolvin D1 on trigeminal neuralgia. Methods Healthy SD rats were randomly divided into model group, resolvin D1 (30, 90, and 270 μg/kg) groups, and phenytoin positive control group. Using the model of trigeminal neuralgia in rats induced by the intracerebral injection of penicillin G potassium, the effects of resolvin D1 against rigeminal neuralgia were investigated. Healthy SD rats were randomly divided into Sham operation group, model group, resolvin D1 (30, 90, and 270 ng/kg) groups, and phenytoin positive control group. Using the model of trigeminal neuralgia in rats induced by chronic constriction injury of the infraorbital nerve, the effects of resolvin D1 against the trigeminal neuralgia were investigated. Results Resolvin D1 (30, 90, and 270 μg/kg) could significantly prolong the latency of the pain response in rats (the animal screamed, shaked and his hindlimb scratched the face), reduce the pain time of rats within 60 min, and significantly increase the pain threshold induced by chronic constriction injury of the infraorbital nerve. Conclusion Resolvin D1 has the function against trigeminal neuralgia.