目的 研究索法酮在大鼠體內(nèi)的藥動(dòng)學(xué)特點(diǎn)。方法 建立大鼠血漿中索法酮的HPLC檢測(cè)方法，考察大鼠ig給藥索法酮24 h內(nèi)血藥濃度，計(jì)算藥動(dòng)學(xué)參數(shù)。結(jié)果 ig給予100 mg/kg索法酮，Cmax為13.0 mg/kg，AUC為34.7 mg/L。結(jié)論 索法酮在大鼠體內(nèi)吸收特點(diǎn)非常明確，可為索法酮制劑研究提供依據(jù)。

Objective To study in vivo pharmacokinetic characteristics of sofalcone in rats. Methods HPLC method was established to determine the sofalcone in rat’s plasma, and investigate the blood concentration after ig administration of sofalcone to rats in 24 h, then pharmacokinetic parameters were calculated. Results Sofalcone raw materials were given by ig administration of 100 mg/kg , then the Cmax was 13.0 mg/kg, and the AUC was 34.7 mg/L. Conclusion The absorption characteristic of sofalcone in rats is clear, which provides the basis for the study on the preparation method of sofalcone.

國(guó)家重大新藥創(chuàng)制專項(xiàng)（2011ZX09401-009）；天津市科技支撐計(jì)劃重點(diǎn)項(xiàng)目（10ZCKFSH01300）