目的 建立離子色譜法測定碳酸司維拉姆中氯化物的檢測分析方法。方法 色譜柱為Rfic IonPac AS11-HC分析柱（250 mm×4 mm），Rfic IonPac AG11-HC保護(hù)柱（50 mm×4 mm），淋洗液為20 mmol/L KOH溶液，檢測器為DS5電導(dǎo)檢測器，抑制器電流為49 mA，體積流量為1.0 mL/min，柱溫為30 ℃，進(jìn)樣體積為10 μL，采集時間為12 min。結(jié)果 氯離子在0.50～10 μg/mL線性關(guān)系良好（r＝0.999 4），平均回收率為99.27%，RSD值為1.57%。結(jié)論 本法快速、準(zhǔn)確、可靠，可用于碳酸司維拉姆中氯化物的測定。

Objective To establish an ion chromatographic method for the determination of chloride content in sevelamer carbonate. Methods The determination was performed on Rfic IonPac anion exchange column (AS11-HC, 250 mm × 4 mm) and Rfic IonPac anion protective column (AG11-HC, 50 mm × 4 mm), with eluant of 20 mmol/L KOH solution by conductivity detector at a flow rate of 1.0 mL/min. The column temperature was 30 ℃, injection volume was 10 μL, and acquisition time was 12 min. Results The linear range of chloride ion was 0.50 — 10 μg/mL (r=0.999 4), and the average recovery was 99.27% with RSD value 1.57%. Conclusion This method is rapid, accurate, reliable and can be used for the determination of chloride in sevelamer carbonate.