目的 觀察甲基強(qiáng)的松龍聯(lián)合環(huán)磷酰胺治療Churg-Strauss綜合征（CSS）的臨床療效及安全性。方法 回顧性分析2004年1月至2012年5月4例伴有腎損害的CSS病例應(yīng)用甲基強(qiáng)的松龍聯(lián)合環(huán)磷酰胺治療的療效及安全性。結(jié)果 CSS伴腎臟受累者應(yīng)用甲基強(qiáng)的松龍聯(lián)合環(huán)磷酰胺治療后，均獲得臨床緩解，且腎功能恢復(fù)良好，同時(shí)未見(jiàn)明顯不良反應(yīng)。結(jié)論 甲基強(qiáng)的松龍聯(lián)合環(huán)磷酰胺治療合并腎臟損害的CSS治療有效，且不良反應(yīng)小。

Objective To observe the efficacy and safety of methyl prednisolone combined with cyclophosphamide in treatment of Churg-Strauss syndrome (CSS). Methods The efficacy and safety of methyl prednisolone combined with cyclophosphamide in four patients diagnosed as CSS with kidney injury during January 2004 and November 2012 were retrospectively analysed. Results All the patients achieved the total clinical remission and recovery of renal function after treated with methyl prednisolone and cyclophosphamide without obvious side effects. Conclusion Methyl prednisolone combined with cyclophosphamide is effective to CSS with kidney injury without obvious side effects.