目的 觀察左布比卡因頸椎旁神經(jīng)阻滯聯(lián)合臭氧治療青少年頸源性頭痛的臨床療效。方法 將患有頸源性頭痛的青少年患者168例隨機(jī)分為對照組（84例）和治療組（84例）。對照組應(yīng)用左布比卡因行頸椎旁神經(jīng)阻滯，治療組在對照組基礎(chǔ)上加用臭氧進(jìn)行治療，2～3次為1個(gè)療程，兩組各治療1個(gè)療程。兩組患者治療前及治療結(jié)束后7 d、1個(gè)月和3個(gè)月進(jìn)行評價(jià)臨床療效和不良反應(yīng)。結(jié)果 與治療前相比，兩組患者治療后7 d、1個(gè)月、3個(gè)月的VAS評分均有明顯降低，其差異具有統(tǒng)計(jì)學(xué)意義（P＜0.05）。在治療后7 d治療組的疼痛評分、頭痛發(fā)作次數(shù)及每次發(fā)作時(shí)間與對照組相比均明顯降低，差異均具有統(tǒng)計(jì)學(xué)意義（P＜0.05）；治療組在治療后7 d，治愈32例，明顯好轉(zhuǎn)39例，顯效率為84.5%，同期，對照組治愈21例，明顯好轉(zhuǎn)31例，顯效率為61.9%，對照組顯效率明顯低于治療組，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05），且無不良反應(yīng)發(fā)生。結(jié)論 左布比卡因頸椎旁神經(jīng)阻滯療法聯(lián)合臭氧治療青少年頸源性頭痛的臨床療效優(yōu)于單純頸椎旁神經(jīng)阻滯，值得臨床應(yīng)用。

Objective To explore the clinical efficacy of paravertebral neural blockade by levobupivacaine combined with ozone for cervicogenic headache among the adolescent patients. Methods A total of 168 cases with cervicogenic headache were randomly divided into control (84 cases) and treatment (84 cases) groups. The patients in the control group were treated with the method of pure paravertebral neural blockade and the patients in the treatment group were treated with paravertebral neural blockade combined with ozone. Each case had a course of 2—3 times’ treatment. The clinical efficacy and adverse effect were compared at the time of before the treatment and 7 d, 1 month, and 3 months after the treatment. Results Compared with the situation before the treatment, receiving the treatment 7 d, 1 month, and 3 months later, VAS scores in both groups were significantly lower than before and had the statistically significant difference (P<0.05). Pain scores, the number of headache attacks and the duration in the test group were significantly lower than those in the control group 7 d after the treatment. In the treatment group, 32 cases were cured and 39 cases were significantly improved with the efficacy rate of 84.5% 7 d after the treatment. At the same time, in the control group, 21 cases were cured and 31 cases were significantly improved with the efficacy rate of 61.9%, which was significantly lower than those in the treatment group and had the statistically significant difference (P<0.05). No adverse effect was observed in the test group. Conclusion The clinical efficacy of paravertebral neural blockade by levobupivacaine combined with ozone for cervicogenic headache among the adolescent patients is better than the method of paravertebral neural blockade only, which is worthy of clinical application.