目的 對(duì)咪達(dá)那新的合成工藝進(jìn)行研究。方法 以二苯乙腈為起始原料，與1,2-二溴乙烷經(jīng)相轉(zhuǎn)移反應(yīng)生成4-溴-2,2-二苯基丁腈（1），化合物1在三乙胺存在下，于N,N-二甲基甲酰胺–二甲基亞砜中與2-甲基咪唑反應(yīng)，生成4-(2-甲基-1H-咪唑-1-基)-2,2-二苯基丁腈（2），化合物2在70%硫酸溶液中，經(jīng)水解、精制得咪達(dá)那新。結(jié)果 該合成工藝總收率為40.2%，終產(chǎn)物質(zhì)量分?jǐn)?shù)為99.9%。結(jié)論 工藝改進(jìn)后，簡(jiǎn)化了操作過程，提高了咪達(dá)那新的收率。

Objective To study the synthetic technology of imidafenacin. Methods Using 1,2-dibromomethane as the starting material, 4-bromo-2,2-diphenylbutyronitrile (1) was obtained after the phase transfer reaction with diphenylacetonitrile; compound 1 was then condensed with 2-methylimidazole in the presence of triethylamine in hot DMF-DMSO to obtain 4-(2-methyl-1-imidazolyl)- 2,2-diphenylbutyronitrile (2). Imidafenacin was obtained according to the hydrolysis of compound 2 in the presence of 70% sulfuric acid. Results The total yield by the synthetic process was 40.2%, and the purity of imidafenacin was 99.9%. Conclusion After the improvement of the process, the operating process is simplified and the yield of imidafenacin is improved.