目的 研究注射用炎琥寧對(duì)脂多糖發(fā)熱模型家兔血清中細(xì)胞因子（TNF-α、IL-1β、IL-6、cAMP、PGE2）和下丘腦中升溫介質(zhì)（cAMP、PGE2）的影響。方法 建立家兔脂多糖（10 EU/kg）發(fā)熱模型，監(jiān)測(cè)不同時(shí)間點(diǎn)注射用炎琥寧對(duì)脂多糖發(fā)熱模型家兔體溫影響，繪制平均升溫曲線；模型升溫峰值時(shí)收集指標(biāo)，ELISA法檢測(cè)血清中細(xì)胞因子、下丘腦中升溫介質(zhì)變化。結(jié)果 注射用炎琥寧能顯著降低脂多糖發(fā)熱模型家兔的體溫，且量效關(guān)系較顯著；注射用炎琥寧能顯著抑制發(fā)熱模型家兔血清中IL-6、cAMP、PGE2增加和下丘腦中cAMP、PGE2的釋放。結(jié)論 注射用炎琥寧對(duì)脂多糖發(fā)熱模型家兔有較好的解熱作用，其解熱效果可能與其抑制外周IL-6、cAMP、PGE2增加和下丘腦cAMP、PGE2釋放有關(guān)。

Objective To explore the effects of Potassium Sodium Dehydroandroan Drographolide Succinate for injection (PSDDSI) on the cytokines (TNF-α, IL-1β, IL-6, cAMP, and PGE2) in serum and the fever neurotransmitters (cAMP, PGE2) in hypothalamus of rabbits in lipopolysacchride (LPS)-induced febris response. Methods he LPS-induced febris response in rabbits (10 EU/kg) was established. The body temperature of rabbits administered with PSDDSI in LPS-induced febris response was detected at different time points, and an average temperature rising curve was drawn. The indicators at warming peak time of the model were collected, and the contents of cytokines in the serum and fever neurotransmitters media in the hypothalams were measured by ELISA-Kits method. Results PSDDSI could significantly reduce the body temperature of rabbits in LPS-induced febris response, and the dose-effect relationship was very significant; PSDDSI could significantly inhibit the release of IL-6 and cAMP in serum and PGE2 and cAMP in hypothalamus of rabbits in LPS-induced febris response. Conclusion PSDDSI has a good antipyretic effect on LPS-induced febris response in rabbits. The mechanism may be related to the inhibition of cytokines in the serum and the fever neurotransmitters in the hypothalamus.