目的 將蒙花苷制備成固體分散體，提高其體外溶出度。方法 分別以不同輔料為載體，采用溶劑法、熔融法或溶劑–熔融法制備蒙花苷固體分散體，以蒙花苷的體外溶出度為指標，考察蒙花苷固體分散體的最佳處方和制備工藝。并采用差示熱分析法和X射線粉末衍射法對蒙花苷固體分散體物相進行表征。結果 蒙花苷與聚乙二醇6000質量比為1∶9，采用熔融法制備的固體分散體的體外溶出最好。結論 以聚乙二醇6000為載體制備的蒙花苷固體分散體可以顯著提高蒙花苷的體外溶出度，且以過飽和的固態(tài)溶液或無定型狀態(tài)均勻分布在載體中。

Objective To prepare linarin solid dispersion and improve the dissolution rate of linarin in vitro. Methods The solid dispersion of linarin was prepared by the solvent, melted, and solvent-melted methods with different excipients as carriers, respectively. To study the best prescription and preparation process, the dissolution characteristics of the solid dispersion in vitro were measured by HPLC, and properties of solid dispersion were studied by DSC and X-ray. Results The in vitro dissolution of linarin solid dispersion prepared by the melted method was the best with linarin-poly ethylene glycol (PEG) 6000 (1∶9). Conclusion The in vitro dissolution of linarin is significantly increased by linarin solid dispersion prepared by melted method with PEG 6000 as the carrier. Linarin is completely dispersed in carriers with supersaturated solid solution or amorphous state.