目的 觀察左氧氟沙星膠囊聯(lián)合癃清片治療2型糖尿病合并尿路感染的療效和安全性。方法 選取平邑縣人民醫(yī)院2012年10月—2013年10月住院的2型糖尿病合并尿路感染患者209例，將其隨機(jī)分為治療組（105例）和對(duì)照組（104例），所有患者根據(jù)病情分別選用口服降糖藥和（或）胰島素控制血糖，并根據(jù)血糖情況調(diào)整降糖方案，使血糖控制理想。對(duì)照組患者口服鹽酸左氧氟沙星膠囊，2粒/次，2次/d；治療組在對(duì)照組基礎(chǔ)上口服癃清片，6片/次，2次/d，兩組均治療7 d。觀察治療前后患者的臨床癥狀、尿常規(guī)變化和不良反應(yīng)。結(jié)果 治療組和對(duì)照組有效率分別為95.2%、76.9%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）；治療后，患者尿常規(guī)中白細(xì)胞和紅細(xì)胞計(jì)數(shù)均顯著減少，治療組減少更加明顯，差異具有統(tǒng)計(jì)學(xué)意義（P＜0.05）。胃部不適為最常見的不良反應(yīng)，兩組間差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論 左氧氟沙星膠囊聯(lián)合癃清片治療2型糖尿病合并尿路感染有很好的療效，治療過(guò)程中的不良反應(yīng)較少，值得臨床應(yīng)用。

Objective To observe the efficacy and safety of Levofloxacin Capsules combined with Longqing Tablets in the treatment of type 2 diabetes mellitus with urinary tract infection. Methods The patients (209 cases) diagnosed with type 2 diabetes mellitus with urinary tract infection in the People’s Hospital of Pingyi County from October 2012 to October 2013 were randomly divided into treatment (105 cases) and control (104 cases) groups. All the patients were given different oral medications and/or insulin according to their condition to control blood sugar, and the treatment was regulated according to the changes of blood sugar. The patients in the control group were po administered with Levofloxacin Capsules, once 2 capsules, twice daily. The patients in the treatment group were po administered with Longqing Tablets, once 6 pieces, twice daily, and other treatment was the same as the control group. Two groups were treated for 7 d. Clinical symptoms, routine urine changes, and adverse reactions were observed before and after the treatment. Results The efficiency for the patients in both the treatment and control groups was 95.2% and 76.9% with the significant difference (P < 0.05). The white and red blood cells in urine decreased significantly compared with those before the treatment, and the treatment group decreased significantly compared with the control group (P < 0.05). Upset stomach was the most frequent adverse reaction, and there was no significant difference between two groups. Conclusion Levofloxacin Capsules combined with Longqing Tablets has an accurate curative effect on type 2 diabetes mellitus with urinary tract infection with low incidence of adverse drug reactions, which could be used in clinic.