目的 研究輸液相關(guān)不良事件與給藥劑量因素間的相關(guān)性，確證影響輸液相關(guān)不良事件的主要因素，以期減少輸液相關(guān)不良事件的發(fā)生率。方法 以前瞻性及回顧性的隊(duì)列研究方法對(duì)輸液相關(guān)不良事件與給藥劑量因素的相關(guān)性進(jìn)行研究。根據(jù)照納入及排除標(biāo)準(zhǔn)篩選研究對(duì)象，接受輸液治療的患者中暴露于某一研究因素的為暴露組，未暴露于這一因素的為非暴露組。觀察兩組中不良反應(yīng)（ADRs）的發(fā)生情況。利用SPSS 15.0軟件對(duì)研究數(shù)據(jù)進(jìn)行χ2檢驗(yàn)。分析兩組間ADRs發(fā)生率及計(jì)算相對(duì)危險(xiǎn)度（RR）。結(jié)果 兩組輸液不良反應(yīng)發(fā)生率有明顯差異（P＜0.05）。結(jié)論 給藥劑量合理性與輸液不良反應(yīng)發(fā)生率相關(guān)。

Objective To study the correlation between the adverse transfusion reactions and the dosage factor, to corroborate the main factors related to the adverse transfusion reactions, and to decrease the incidence of adverse transfusion reactions. Methods A prospective and retrospective cohort study method was used to study the correlation between adverse transfusion reactions and dosage factors including dripping rate and dosage. The patients were screened and grouped according to inclusive and exclusive criteria. Among the patients with transfusion treatment, those exposed to some research factors were grouped in exposure group, while those not exposed to the same research factor were grouped in non-exposed group. The incidence of adverse transfusion reactions was observed. The data were analyzed with χ2 test method which could be performed by SPSS 15.0 software. The incidence of adverse transfusion reactions in two groups and the relative risk were analyzed. Results There were significant differences between the rationality of dosage factor and the incidences of adverse events (P < 0.05). Conclusion The rationality of dosage factor was correlated with the rate of adverse transfusion reactions.