目的 觀察祛栓靈膠囊對(duì)急性血瘀模型動(dòng)物兔和大鼠的血液流變學(xué)的影響。方法 動(dòng)物ig祛栓靈膠囊7 d后，分別以iv 10%高分子右旋糖酐和sc腎上腺素加冰浴制備兔和大鼠急性血瘀模型，然后分別測(cè)定血液流變學(xué)指標(biāo)的變化。結(jié)果 兔連續(xù)ig祛栓靈膠囊37.5～150 mg/kg 7 d后，可降低高分子右旋糖酐血瘀模型兔的全血黏度、全血還原黏度和紅細(xì)胞聚集指數(shù)。大鼠連續(xù)ig祛栓靈膠囊62.5～250 mg/kg 7 d后，同樣可降低sc腎上腺素＋冷刺激所致急性血瘀模型大鼠的全血黏度、血漿黏度、紅細(xì)胞壓積和纖維蛋白原。結(jié)論 祛栓靈膠囊對(duì)急性血瘀兔和大鼠的血液流變學(xué)指標(biāo)具有一定的改善作用。

Objective To observe the effects of Qushuanling Capsule on the hemorheology in rabbits and rats with acute blood stasis. Methods After the animals were ig given Qushuanling Capsule for 7 d, the models of acute blood stasis were established by means of iv giving rabbits 10% high molecular dextran solution and sc giving rats adrenalin plus swim in ice-bath, respectively. The changes of hemorheology were then observed. Results After ig administration for 7 d, Qushuanling Capsule at 37.5－150 mg/kg could decrease the whole blood viscosity, whole blood reduced viscosity, and erythrocyte aggregation index in rabbits with acute blood stasis. Qushuanling Capsule at 62.5 — 250 mg/kg could also decrease the whole blood viscosity, plasma viscosity, hematocrit and fibrinogen in rats with acute blood stasis. Conclusion Qushuanling Capsule could improve the indexes of hemorheology in rabbits and rats with acute blood stasis in some extent.