目的 研究連續(xù)iv給予丹紅注射液對SD大鼠產生的亞慢性毒性作用。方法 SD大鼠80只，雌雄各半，隨機分為對照組和丹紅注射液600、200、60 mg/kg劑量組，每組20只，連續(xù)iv給藥13周，以其體質量、血液生化學、血液學、臟器相對質量、組織病理學檢查為指標，全面評價其對大鼠的毒性作用。結果 丹紅注射液600 mg/kg組大鼠體質量增長明顯延緩，腎功能指標（BUN、Cr）明顯增加，組織病理學檢查表明腎臟發(fā)生病變。結論 iv給予丹紅注射液600 mg/kg對大鼠有明顯的腎臟毒性。

Objective To investigate the subchronic toxicity of Danhong Injection in rats by continuous iv injection. Methods Eighty SD rats (males and females) were randomly devivided into control group and Danhong Injection in 3 different dosage groups (600, 200, and 60 mg/kg, 20 in each group). The rats were administered with Danhong Injection by continuous iv injection for 13 weeks. The body weight, blood biochemistry, hematology, viscera relative weight, and histopathology were measured for the overall toxicity assessment. Results The normal rats administered with Danhong Injection (600 mg/kg) significantly reduced the growth of body weight and showed abnormal escalation of the levels of urea nitrogen (BUN), creatinine (CR). Pathological changes of kidney were found by histopathological examination. Conclusion Danhong Injection with dosage of 600 g/kg has the significant toxicity on kidney by iv injection.