目的 考察制備的芒果苷脂質(zhì)體的理化性質(zhì)和經(jīng)皮滲透性能。方法 采用薄膜分散法制備芒果苷脂質(zhì)體，超速離心法測(cè)定包封率，并對(duì)粒徑、電位進(jìn)行表征；以大鼠皮膚為滲透屏障，采用Franz擴(kuò)散池比較芒果苷脂質(zhì)體和水溶液的體外經(jīng)皮累積滲透量。結(jié)果 芒果苷脂質(zhì)體的粒徑為（97.7±1.2）nm、電位為（?10.7±0.2）mV，包封率為44.1%。芒果苷脂質(zhì)體組與水溶液組24 h累積滲透量分別為（171.9±13.43）、（102.5±3.97）μg/cm2。結(jié)論 脂質(zhì)體給藥系統(tǒng)可有效促進(jìn)芒果苷的經(jīng)皮滲透，為芒果苷經(jīng)皮給藥新制劑的研究提供了參考。

Objective To investigate the physicochemical property and percutaneous permeability of mangiferin liposomes. Methods Film dispersion method was used to prepare mangiferin liposomes and entrapment efficiency was determined by ultracentrifugation. Particle size and Zeta potential were characterized. Using rat skin as a permeability barrier, accumulation of percutaneous penetration in vitro between mangiferin liposomes and aqueous was compared in Franz diffusion cell. Results The particle size, Zeta potential, and encapsulation efficiency of mangiferin liposomes were (97.7 ± 1.2) nm, (?10.7 ± 0.2) mV, and 44.1%, respectively. The cumulative permeation amount of mangiferin liposome and aqueous was (171.9 ± 13.43) and (102.5 ± 3.97) μg/cm2. Conclusion Liposome delivery system could effectively promote the percutaneous penetration of mangiferin, and provide the experimental reference for new mangiferin transdermal preparations study.