目的 觀察右美托咪定聯(lián)合靜脈麻醉藥抑制止血帶引起的高血壓的臨床療效和安全性。方法 選擇術(shù)中需止血帶行下肢骨科手術(shù)患者50名，隨機(jī)分為對(duì)照組（25例）和治療組（25例），對(duì)照組用丙泊酚復(fù)合瑞芬太尼維持麻醉，治療組用右美托咪定、丙泊酚復(fù)合瑞芬太尼維持麻醉。比較兩組術(shù)中止血帶相關(guān)性高血壓出現(xiàn)時(shí)間及發(fā)生率、術(shù)中患者生命體征和術(shù)后不良反應(yīng)。結(jié)果 對(duì)照組止血帶相關(guān)性高血壓出現(xiàn)時(shí)間早于治療組，止血帶相關(guān)性高血壓發(fā)生率高于治療組（P＜0.05）。治療組術(shù)中血流動(dòng)力學(xué)變化較對(duì)照組平穩(wěn)。對(duì)照組術(shù)后不良反應(yīng)發(fā)生率高于治療組（P＜0.05）。結(jié)論 右美托咪定聯(lián)合靜脈麻醉藥可以在一定程度上抑制止血帶引起的血壓升高并降低止血帶相關(guān)性高血壓發(fā)生率，減少術(shù)后不良反應(yīng)的發(fā)生。

Objective To observe the clinical effect and safety of dexmedetomidine combined with intravenous anesthetics in suppressing tourniquet-induced hypertension. Methods Patients (50 cases) who were undergoing orthopaedic surgeries of the lower extremities on tourniquet inflation were randomly divided into the treatment (25 cases) and control (25 cases) groups. In the control group, the patients were induced with propofol compound fentanyl to maintain anesthesia; while the patients in the treatment group were induced with dexmedetomidine, propofol compound fentanyl to maintain anesthesia. The rates of tourniquet-induced hypertension, the time point of developing to tourniquet-induced hypertension, the vital signs and adverse effects after surgery were compared between the two groups. Results The time point that patients developed to tourniquet-induced hypertension was earlier in the control group than that in the treatment group (P < 0.05), the rate that patients developed to tourniquet-induced hypertension was higher in the control group than that in the treatment group (P < 0.05). Intraoperative hemodynamic of the treatment group changed more smoothly than that in the control group. The incidence of postoperative adverse reaction in the control was higher than that in the treatment group (P < 0.05). Conclusion Dexmedetomidine combined with intravenous anesthetics could suppress the tourniquet to a certain extent caused by increased blood pressure, and could reduce the incidence of high blood pressure with tourniquet correlation, which could reduce the occurrence of postoperative adverse reactions.