目的 分析賀州市人民醫(yī)院銅綠假單胞菌的分布及耐藥性變遷，為指導(dǎo)臨床合理使用抗菌藥物提供可靠依據(jù)。方法 回顧性分析2009—2013年賀州市人民醫(yī)院臨床各科室送檢標(biāo)本分離的銅綠假單胞菌，采用紙片擴(kuò)散法測定抗菌藥物的敏感性。結(jié)果 5年間送檢標(biāo)本共分離出1 544株銅綠假單胞菌，檢出率為16.9%。銅綠假單胞菌的標(biāo)本來源以痰液為主，占78.2%，主要來自呼吸內(nèi)科、ICU、神經(jīng)內(nèi)科，分別占29.7%、21.2%、17.5%。藥敏結(jié)果顯示，銅綠假單胞菌對喹諾酮類、亞胺培南、頭孢哌酮/舒巴坦耐藥率相對較低，但對環(huán)丙沙星、氨芐西林、氨芐西林/舒巴坦高度耐藥，且呈逐年上升趨勢。結(jié)論 賀州市人民醫(yī)院臨床分離的銅綠假單胞菌對常用抗菌藥物耐藥性日益嚴(yán)重，因此臨床上應(yīng)重視監(jiān)測病原菌的分布及耐藥趨勢，根據(jù)藥敏結(jié)果合理選擇抗生素，減少耐藥菌株的產(chǎn)生。

Objective To investigate the distribution of pathogenic bacteria and drug resistance of Pseudomonas aeruginosa in People’s Hospital of Hezhou from 2009 to 2013, and to provide the certain reference for directing the clinical medication and reducing the drug resistance. Methods The distribution of P. aeruginosa isolated from various clinical specimens from 2009 to 2013 was retrospectively analyzed. The antibiotic susceptibility of bacteria was tested by disk diffusion method. Results All of 1 544 P. aeruginosa were isolated and the detection rates was 16.9% during the five years. The specimens were mainly obtained from the sputum, accounting for 78.2%. P. aeruginosa isolates were primarily from the Department of Respirtory, ICU, and Department of Neurology, accounting for 29.7%, 21.2%, and 17.5%, respetively. P. aeruginosa had the relative lower drug resistance to imipenem, cefoperazone/sulbactam, but kept higher drug resistance to ciprofloxacin, ampicillin, ampicillin/sulbactam with increasing trend year by year. Conclusion The drug resistance status of P. aeruginosa in People’s Hospital of Hezhou is more and more serious. In order to reduce the occurrence of drug resistance strains and select the antibiotics reasonably and appropriately, the attention to the distribution of pathogen and detection of drug resistance should be paid by the doctors in clinic.