目的 觀察長春西汀聯(lián)合巴曲酶治療突發(fā)性耳聾的臨床療效。方法 選取2013年1月-2014年1月就診于武漢市第三醫(yī)院的突發(fā)性耳聾患者100例，隨機分為治療組和對照組，每組50例。對照組在常規(guī)治療的基礎(chǔ)上靜脈滴注巴曲酶注射液，10 BU/次，隔天1次，共使用5次；治療組靜脈滴注長春西汀注射液，20 mg/d，其他同對照組。兩組均治療10 d。觀察兩組患者的臨床療效，檢測血漿凝血酶原時間（PT）、凝血酶時間（TT）、活化部分凝血活酶時間（APTT）、血漿纖維蛋白原（Fg）和血液流變學(xué)指標變化。結(jié)果 治療后，治療組和對照組的總有效率分別為86%、60%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后兩組患者PT、TT、APTT較治療前延長，治療后兩組Fg水平均低于治療前，同組治療前后差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組和對照組的血漿黏度、全血黏度高切、全血黏度低切、紅細胞壓積均較治療前有所降低，同組治療前后差異有統(tǒng)計學(xué)意義（P<0.05）；治療后，治療組這些指標較對照組改善更加明顯，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 長春西汀聯(lián)合巴曲酶對突發(fā)性耳聾具有較好的臨床療效，可以改善患者血液高凝狀態(tài)和局部微循環(huán)，值得臨床推廣使用。

Objective To observe the clinical efficacy of vinpocetine combined with batroxobin in the treatment of sudden deafness. Methods Patients (100 cases) with sudden deafness for the treatment in Wuhan Third Hospital from January 2013 to January 2014 were randomly divided into treatment and control groups (50 cases in each group). The patients in the control group were iv administered with Batroxobin Injection on the basis of conventional treatment, 10 BU/time, once every other day, and used for 5 times. The patients in the treatment group were iv administered with Vinpocetine Injection, 20 mg/d, and other treatment was the same as the control group. The patients in two groups were treated for 10 d. The total clinical efficacy was observed, and the changes of PT, TT, APTT, Fg, and hemodynamic indexes were detected. The total effective rates of treatment and control groups were 86% and 60%, respectively, with significant difference between the two groups (P < 0.05). After treatment, PT, TT, and APTT was longer, and Fg was lower compared with before treatment in the two groups, and the difference was statically significant in the same group before and after treatment (P < 0.05). After treatment, plasma viscosity, whole blood high shear viscosity, low sheer viscosity, and blood hematocrit were lower compared with those before treatment in the two groups, and the difference was statically significant in the same group before and after treatment (P < 0.05). After treatment, those indexes in the treatment group were improved more obvious than those in the control group, with significant difference between the two groups (P < 0.05). Conclusion Vinpocetine combined with batroxobin has a good clinical efficacy in the treatment of sudden deafness, and can improve the blood high condensation state and local microcirculation of patients, which is worthy of clinical application.

國家自然科學(xué)基金資助項目（30872864）