目的 探討改性幾丁質(zhì)噴霧劑對口腔潰瘍的改善作用。方法 選取2011年6月-2013年12月到梧州市紅十字會醫(yī)院口腔科就診的口腔潰瘍患者90例，隨機(jī)分為改性幾丁質(zhì)組（30例）、康復(fù)新液組（30例）、對照組（30例），治療前所有患者漱口保持口腔清潔，改性幾丁質(zhì)組患者采用改性幾丁質(zhì)噴霧劑噴到患處，作用3 min后漱口，3次/d；康復(fù)新液組含康復(fù)新液3 min后吞服，10 mL/次，3次/d；對照組采用0.9%氯化鈉注射液含漱，停留3 min，3次/d。3組用藥直至口腔潰瘍愈合。3組均服用維生素A、C、B₂等藥物5 d。比較3組患者灼痛消失時間、紅腫消失時間、潰瘍愈合時間、治療時間和總有效率。結(jié)果 改性幾丁質(zhì)組、康復(fù)新液組、對照組的總有效率分別為100.0%、83.3%、60.0%，對照組的總有效率與其他兩組比較差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）；改性幾丁質(zhì)組的總有效率顯著高于康復(fù)新液組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。改性幾丁質(zhì)組、康復(fù)新液組的灼痛消失時間、紅腫消失時間、潰瘍愈合時間和治療時間均明顯短于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；改性幾丁質(zhì)組的這些觀察指標(biāo)均明顯短于康復(fù)新液組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 改性幾丁質(zhì)噴霧對口腔潰瘍有較好的臨床療效，能顯著縮短疼痛和愈合時間，值得臨床推廣應(yīng)用。

Objective To explore the curative effect of modified chitin spray in improvement of oral ulcers. Methods Patients (90 cases) with oral ulcers for the treatment in Department of Stomatology, Wuzhou Red Cross Hospital during June 2011 to December 2013 were randomly divided into modified chitin, Kangfuxin Liquid, and control groups (30 cases in each group). All the patients rinsed mouth to keep oral cavity clean before treatment. The patients in modified chitin group were treated with modified chitin spray onto the affected area for 3 min and rinsed mouth, 3 times daily. The patients in Kangfuxin Liquid group were treated with Kangfuxin Liquid in mouth for 3 min and than swallowed, 10 mL/time, 3 times daily. Patients in control group used 0.9% Sodium Chloride Injection for mouthwash, and stayed for 3 min, 3 times daily. The patients in three groups were administered until the ulcer healing. All patients took vitamins A, C, and B₂ for 5 d. The burn disappearing time, swelling disappearing time, ulcer healing time, treatment time, and total effective rate in three groups were compared. Results The efficacies on the patients in modified chitin, Kangfuxin Liquid, and control groups were 100.0%, 83.3%, and 60.0%, and total effective rate in the control group was lower than that in the other two groups with significant difference between the two groups (P < 0.05). The total effective rate in modified chitin group was higher than that in Kangfuxin Liquid group with significant difference (P < 0.05). The burn disappearing time, swelling disappearing time, ulcer healing time, and treatment time in modified chitin and Kangfuxin Liquid groups were significantly shorter than those in the control group with significant difference (P < 0.05). Those indexes in modified chitin group were significantly lower than those in Kangfuxin Liquid group with significant difference between the two groups (P < 0.05). Conclusion Modified chitin spray has a good clinical efficacy in the treatment of oral ulcers, and can significantly reduce the pain and healing time, which is worthy of clinical popularization and application.

教育部高等學(xué)校博士學(xué)科點(diǎn)專項(xiàng)科研基金資助項(xiàng)目（20100101120114）