目的 探討金芪降糖片聯(lián)合二甲雙胍治療2型糖尿病的臨床療效和對(duì)血管內(nèi)皮功能的影響。方法 選取2012年12月-2013年10月就診于吉林油田總醫(yī)院的2型糖尿病患者68例，隨機(jī)分為治療組（34例）和對(duì)照組（34例）。兩組患者均進(jìn)行糖尿病教育，均在糖尿病飲食、適當(dāng)運(yùn)動(dòng)的基礎(chǔ)上口服鹽酸二甲雙胍片，0.5 g/次，根據(jù)血糖水平調(diào)整每日劑量，最大劑量<2 g，3次/d；治療組口服金芪降糖片，7片/次，3次/d，餐前0.5 h口服，其他同對(duì)照組。4周為1個(gè)療程，兩組患者均治療2個(gè)療程。觀察兩組患者的臨床療效，同時(shí)測(cè)定兩組患者治療前后糖代謝指標(biāo)、血脂指標(biāo)、血管內(nèi)皮功能指標(biāo)的變化。結(jié)果 治療后，治療組和對(duì)照組的總有效率分別為97.06%、91.18%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者的空腹血糖（FPG）、餐后2 h血糖（2h PG）、糖基化血紅蛋白（HbAlc）均較治療前明顯降低，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05、0.01），治療后，治療組糖代謝指標(biāo)較對(duì)照組改善更加明顯，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者的總膽固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL-C）均較治療前明顯降低，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05、0.01）；治療后，治療組血脂指標(biāo)較對(duì)照組改善更加明顯，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血清一氧化氮（NO）、內(nèi)皮素（ET）、血栓素B₂（TXB₂）水平均較治療前明顯下降，6-酮-前列腺素1α（6-keto-PGF1α）與治療前比較顯著升高，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05、0.01）；治療后，治療組指標(biāo)較對(duì)照組改善更加明顯，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.01）。結(jié)論 金芪降糖片聯(lián)合二甲雙胍治療2型糖尿病有較好的臨床療效，能較好的控制血糖水平，并可改善患者的血脂代謝和血管內(nèi)皮功能，適合臨床推廣應(yīng)用。

Objective To study the clinical efficacy of Jinqi Jiangtang Tablets combined with metformin in the treatment of type 2 diabetes and the effect on vascular endothelial function. Methods Type 2 diabetic patients (68 cases) in Jilin Oil Fields General Hospital from December 2012 to October 2013 were randomly divided into treatment (34 cases) and control (34 cases) groups. The patients in two groups were given health education on diabetes and oral administration of Metformin Tablets (0.5 g/time) based on diabetes diet and proper exercise, and the daily dose was adjusted according to blood glucose levels, maximum dosage < 2 g, 3 times daily. The patients in the treatment group were po administered with Jinqi Jiangtang Tablets before meals 0.5 h, 7 tablets/time, 3 times daily, and other treatment was the same as the control group. Four weeks was as one period, and two groups were treated for two periods. Before and after the treatment, the clinical effect of the two groups were visualized, and the index changes of sugar metabolism, blood lipid, and vascular endothelial function were detected. Results After treatment, the effective rates in the treatment and control groups were 97.06% and 91.18%, respectively. There was significant difference between two groups (P < 0.05). FPG, 2 h PG, and HbAlc levels were significantly decreased in two groups (P < 0.05), and treatment group was decreased more than control group (P < 0.05 or 0.01). The improvement of TC, TG, and LDL-C in the treatment group was much better than those in the control group (P < 0.05). The levels of ET, NO, and TXB₂ were decreased after treatment in treatment group, and it had significant difference with control group (P< 0.05 or 0.01). The levels of 6-keto-PGF1α in both groups were apparently increased, and the increase of 6-keto-PGF1α in treatment group also had significant difference with control group (P < 0.01). Conclusion Jinqi Jiangtang Tablets combined with metformin has good clinical effect in the treatment of type 2 diabetes, and can better control blood sugar and improve blood lipid metabolism and vascular endothelial function, which is worthy of clinical application.