高烏甲素是從高烏頭Aconitum sinomontanum Nakai內(nèi)提取的二萜類(lèi)生物堿，為非阿片類(lèi)鎮(zhèn)痛藥，臨床上常使用高烏甲素的氫溴酸鹽用于中度以上疼痛的治療。由于高烏甲素的水溶性差、對(duì)光照較敏感，其理化性質(zhì)決定了傳統(tǒng)制劑的臨床應(yīng)用受到一定的限制，使得新型制劑的研究成為一種趨勢(shì)。近年來(lái)，高烏甲素的不同新型制劑被不斷開(kāi)發(fā)以滿足不同的治療目的，綜述了近幾年高烏甲素新型制劑方面的研究進(jìn)展，主要從其藥物載體制劑、緩控釋制劑及速釋制劑3個(gè)方面進(jìn)行了分類(lèi)、歸納和總結(jié)，對(duì)現(xiàn)有問(wèn)題進(jìn)行分析并為后續(xù)研究提供一些參考。

Lappaconitine is a kind of diterpenoid alkaloids extracted from Aconitum sinomontanum Nakai. As a non-opioid analgesic, its hydrobromide is commonly used in the treatment of moderate to severe pain clinically. The clinical application of lappaconitine traditional preparations was limited due to its poor water solubility and sensitivity to light, which made the study of new agents become a trend. In recent years, different formulations of lappaconitine are constantly developed to meet different therapeutic purposes. Research progress on new preparations of lappaconitine was reviewed in recent years. And the information was classified and summarized mainly from three aspects of carrier, sustained-release and immediate-release preparations, to analyse the existing problems and provide some references for further study.

國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973計(jì)劃）資助項(xiàng)目（2012CB724001）