目的 對3-異丁基戊二酰亞胺的合成工藝進(jìn)行研究。方法 以異戊醛為原料，經(jīng)Knoevenagel縮合、Michael加成、水解脫羧、環(huán)合得到目標(biāo)產(chǎn)物。結(jié)果 合成了目標(biāo)化合物，并利用IR、MS和¹H-NMR確證了結(jié)構(gòu)；收率為78.0%，質(zhì)量分?jǐn)?shù)為98.5%。結(jié)論 采用“一勺燴”合成了3-異丁基戊二酰亞胺，操作簡便，設(shè)計(jì)合理，收率較高。

Objective To study the synthetic technology of 3-isobutyl glutarimide. Methods 3-Methyl butanal was used as starting material to synthesize the target compound by Knoevenagel condensation, Michael addition, hydrolysis decarboxylation and cyclization. Results The target compound was synthesized and characterized by IR, MS and ¹H-NMR. The yield was 78.0% and the purity was 98.5%. Conclusion 3-Isobutyl glutarimide is synthesized using the method of "one-pot" which has the advantages of simple operation and reasonable design with high yield.

天津市科技計(jì)劃項(xiàng)目（13ZCZDSY00100）