目的 觀察咳喘膏對(duì)哮喘豚鼠嗜酸細(xì)胞趨化因子、組胺的影響，探討其作用機(jī)制。方法 將豚鼠隨機(jī)分為對(duì)照組，模型組，地塞米松組，咳喘膏穴位貼藥1、3、6 h組，每組各10例。卵蛋白致敏并誘發(fā)哮喘，行穴位貼敷。檢測(cè)各組嗜酸性粒細(xì)胞趨化因子、血組胺水平。結(jié)果 咳喘膏穴位貼敷各組嗜酸性粒細(xì)胞趨化因子、組胺較模型明顯減低。結(jié)論 咳喘膏穴位貼敷可改善豚鼠哮喘氣道炎性反應(yīng)。

Objective To observe the effect of Kechuangao acupoint application on the changes of eotaxin and histamine in asthma guinea pigs and to explore its underlying mechanism. Methods Guinea pigs were randomly divided into normal control group, model group, Dexamethasone group, and Kechuangao acupoint application 1, 3, and 6 h groups. Each group had 10 animals. Asthma model was established by ip injection of ovalbumin and forced inhalation. External application was made on guinea pigs back. Levels of eotaxin and histamine were detected after course of treatment. Results Compared with model group, the levels of eotaxin and histamine decreased significantly in t Kechuangao acupoint application groups, and bettered than others. Conclusion Kechuangao acupoint application can relieve the phlegmonosis injuries in pulmonary tissue of asthma guinea pigs, which may contribute to its therapeutic effect in relieving asthma.