目的 觀察參附強心丸聯(lián)合鹽酸貝那普利治療老年高血壓合并心力衰竭的臨床療效和安全性。方法 將64例老年高血壓合并心力衰竭患者隨機分為治療組和對照組，每組各32例。對照組在常規(guī)治療基礎上口服鹽酸貝那普利片10 mg/次，1次/d；治療組在對照組基礎上口服參附強心丸6 g/次，2次/d。兩組患者均服藥持續(xù)性治療8周。治療結(jié)束后，觀察兩組患者的中醫(yī)癥候療效、心力衰竭療效、心功能指標。結(jié)果 治療后，治療組和對照組在中醫(yī)癥候療效方面的總有效率分別為90.63%、71.88%，差異有統(tǒng)計學意義（P<0.05）；兩組在心力衰竭療效方面總有效率分別為87.5%、71.9%，治療組療效優(yōu)于對照組，差異有統(tǒng)計學意義（P<0.05）；治療組左室射血分數(shù)（LVEF）均較治療前增加，左室舒張末內(nèi)徑（LVEDD）較治療前縮小，血漿腦鈉素（BNP）與治療前比較有明顯下降，治療組療效明顯優(yōu)于對照組，差異有統(tǒng)計學意義（P<0.05）。結(jié)論 參附強心丸聯(lián)合鹽酸貝那普利是治療老年高血壓合并心力衰竭患者的有效方法，值得臨床推廣。

Objective To observe the efficacy and safety of Shenfu Qiangxin Pills combined with benazepril hydrochloride in treatment of senile hypertension with heart failure. Methods Patients (64 cases) with senile hypertension with heart failure were randomly divided into treatment group and control group. Each had 32 cases. On the basis of conventional treatment, the patients in the control group were given Benazepril Hydrochloride Tablets 10 mg/time, once daily; The patients in the treatment group were given Shenfu Qiangxin Pills 6 g/time, twice daily on the basis of the control group. The patients in the two groups were taken continuous treatment for 8 weeks. After the treatment, traditional Chinese medicine syndrome efficacy, heart failure efficacy, and cardiac function indexes were observed. Results After the treatment, the total effective rates for the patients in both the treatment and control groups were 90.63% and 71.88% in traditional Chinese medicine syndrome efficacy with significant difference (P < 0.05). The total effective rates for the patients in both groups were 87.5% and 71.9% in heart failure efficacy, and the treatment group was better than the control group with significant difference (P < 0.05). Compared with the control group, left ventricular ejection fraction (LVEF) increased; Left ventricular end diastolic diameter (LVDD) lessened; Brain natriuretic peptide (BNP) decreased and the treatment group was better than the control group with significant difference (P < 0.05). Conclusion Shenfu Qiangxin Pills combined with benazepril hydrochloride is effective in the treatment of senile hypertension with heart failure, which is worthy of clinical application.

天津市衛(wèi)生局中醫(yī)、中西醫(yī)結(jié)合科研自籌基金課題（200020）