目的 探討血府逐瘀口服液聯(lián)合生長抑素治療急性胰腺炎的臨床療效。方法 選取2012年10月-2014年4月內(nèi)蒙古醫(yī)科大學附屬醫(yī)院收治的急性胰腺炎患者98例，隨機分成治療組（49例）和對照組（49例），對照組在常規(guī)治療的基礎上給予注射用生長抑素0.25 mg/h，經(jīng)微泵持續(xù)靜脈泵注；治療組在對照組治療的基礎上口服血府逐瘀口服液，10 mL/次，3次/d。兩組均連續(xù)治療7 d。觀察兩組患者的臨床療效，同時比較兩組腹痛緩解時間、胃腸功能恢復時間、血尿淀粉酶正常時間、白細胞計數(shù)恢復時間、并發(fā)癥發(fā)生率等臨床指標以及血清腫瘤壞死因子-α（TNF-α）、白細胞介素-1β（IL-1β）、血漿內(nèi)皮素（ET）、血栓素B₂（TXB₂）及6-酮前列腺素-F1α（6-keto-F1α）的水平變化。結(jié)果 治療組和對照組的總有效率分別為95.92%、85.71%，兩組比較差異有統(tǒng)計學意義（P<0.05）。治療組患者在腹痛緩解時間、胃腸功能恢復時間、血尿淀粉酶恢復時間、白細胞計數(shù)恢復時間、并發(fā)癥發(fā)生率方面均顯著低于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組患者的TNF-α、IL-1β、ET、TXB₂、6-keto-PGF1α均較治療前有顯著降低，同組治療前后差異有統(tǒng)計學意義（P<0.05、0.01）。治療后，治療組這些指標明顯低于對照組，兩組比較差異有統(tǒng)計學意義（P<0.05、0.01）。結(jié)論 血府逐瘀口服液聯(lián)合生長抑素對急性胰腺炎有較好的臨床療效，可能與減輕患者的炎癥反應，改善微循環(huán)有關。

Objective To investigate the therapeutic efficacy of Xuefu Zhuyu Oral Liquid combined with somatostatin in the treatment of acute pancreatitis. Methods Patients (98 cases) suffered from acute pancreatitis in Affiliated Hospital of Inner Mongolia Medical University from October 2012 to April 2014 were randomly divided into treatment (49 cases) and control (49 cases) groups. The patients in the control group were given somatostatin 0.25 mg/h through micro-vein continuous iv pumping on the basis of conventional treatment. The patients in the treatment group were po administered with Xuefu Zhuyu Oral Liquid, 10 mL/time, three times daily. All the patients were treated continuously for 7 d. The total clinical efficacy was observed, and clinical indicators such as abdominal pain relief time, gastrointestinal function recovery time, blood and urine amylase turn normal time, white blood cell count recovery time, and incidence of complications were compared. At the same time, the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), endothelin (ET), thromboxane B₂ (TXB₂), and 6-keto-prostaglandin-F1α (6-keto-F1α) were compared. Rcsults The total effective rates of the treatment and control groups were 95.92% and 85.71%, respectively, with the significant difference between the two groups (P < 0.05). Abdominal pain relief time, gastrointestinal function recovery time, blood and urine amylase turn normal time, white blood cell count recovery time, and incidence of complications in the treatment group were significantly lower than those in the control group, with the significant difference between the two groups (P < 0.05). After the treatment, the levels of TNF-α, IL-1β, ET, TXB₂, and 6-keto-PGF1α in the two groups were significantly lower than before the treatment, with statistically significant difference before and after treatment in the same group (P < 0.05, 0.01). After the treatment, those indexes in the treatment group were significantly lower than those in the control group, with the significant difference between the two groups (P < 0.05, 0.01).Conclusion Xuefu Zhuyu Oral Liquid combined with somatostatin has a good clinical efficacy in the treatment of acute pancreatitis, and the mechanism may be related to reducing the inflammation and improving microcirculation.