目的 對2010-2013年中國人民解放軍海軍總醫(yī)院156例左氧氟沙星不良反應(yīng)（ADR）報告進行回顧性分析，探討左氧氟沙星不良反應(yīng)出現(xiàn)的時辰及規(guī)律，從而為不同時間的合理用藥積累依據(jù)。方法 對4 141例住院患者病歷進行回顧性分析，收集左氧氟沙星不良反應(yīng)出現(xiàn)的時辰、嚴重程度和臨床表現(xiàn)，并進行圓分布資料的統(tǒng)計學(xué)分析。結(jié)果 左氧氟沙星不良反應(yīng)以戌時發(fā)生率為最高，達2.86%，高于其他時辰，差異具有統(tǒng)計學(xué)意義（Watson-William F=17.523，P=0.000）；對不同時辰不良反應(yīng)嚴重程度分析發(fā)現(xiàn)，戌時和子時重度所占比例達27.27%、25.00%，嚴重程度較高，與其他時辰相比差異具有統(tǒng)計學(xué)意義（Ridit Z=9.321，P=0.000）；不同時辰不良反應(yīng)臨床表現(xiàn)不同。結(jié)論 左氧氟沙星不良反應(yīng)具有時間特異性，這對于臨床用藥具有指導(dǎo)意義。

Objective One hundred and fifty-six cases with adverse drug reaction (ADR) by Levofloxacin in Navy General Hospital of PLA were analyzed retrospectively from 2010 to 2013, in order to investigate the occurrence time and regularity of adverse reaction about Levofloxacin, resulting in the accumulation of the evidence for rational use of drugs in different time. Methods The medical record of 4 141 cases for hospitalized patients were analyzed retrospectively, the hour, severity, and clinical manifestations were collected,, and the data were analyzed by circular distribution. Results The incidence rate of ADR for Levofloxacin in the period of the day from 7 pm to 9 pm was up to 2.86%, the difference was statistically significant to other times (Watson-William, F=17.523, P=0.000). The severity analysis found, severe accounted for 27.27% and 25% in the period of the day from 7 pm to 9 pm and the one from 11 pm to 1 am, serious degree was higher than those at the other time (Ridit, Z=9.321, P=0.000). The ADR in clinical manifestations was different in different time, and the difference was statistically significant. Conclusion The ADR of Levofloxacin has temporal specificity, which is of guiding significance for clinical medication.