酶抑制劑類抗糖尿病藥物是目前藥物研究的熱點(diǎn)，而藥物篩選技術(shù)是制約此類抗糖尿病新藥研發(fā)速度的關(guān)鍵步驟。主要從分子水平總結(jié)近年來報(bào)道的與糖尿病相關(guān)的酶抑制劑類候選藥物的篩選方法，包括傳統(tǒng)方法和前沿方法，著重介紹極具潛力的毛細(xì)管電泳法、質(zhì)譜法、生物傳感法和微通道篩選方法等。

Various enzyme inhibitors have been demonstrated to be a hotspot in the research area of anti-diabetic drugs, whose development has been greatly limited by the efficiency of diverse drug screening methods. This paper concerns on different types of drug screening methods in the molecular level for enzyme inhibitors used in diabete treatment, including both traditional and advanced methods. Importantly, several screening methods with great potential have been emphasized here, such as capillary electrophoresis, mass spectrometry, biosensors, screening methods based on microchannel and so on.