1H-NMR確證了結(jié)構(gòu)，此路線所得產(chǎn)品收率為62.1%。結(jié)論 此路線操作簡單，成本低廉，設(shè)計(jì)合理，收率高，適合該化合物的工業(yè)化生產(chǎn)。;Objective To study the synthetic technology of 4-chloro-2-oxo-1,2-dihydroquinoline-3-carbaldehyde. Methods N1, N3-diphenylmalonamide was used as starting material to synthesize the target compound by ammonolysis of ester, cyclization, methylation of amine, and hydrolysis reaction. Results The target compound was synthesized and characterized by MS and 1H-NMR. The yield of this route was 62.1%. Conclusion The synthetic route for the compound has the advantages of simple operation, low cost, reasonable design, and high yield, which is suitable for the industrial production of the compound."/>

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首頁 > 過刊瀏覽>2014年第29卷第10期 >2014,29(10):1083-1085. DOI:10.7501/j.issn.1674-5515.2014.10.002
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4-氯-2-氧代-1,2-二氫喹啉-3-甲醛的合成工藝研究

Synthesis of 4-chloro-2-oxo-1,2-dihydroquinoline-3-carbaldehyde

發(fā)布日期：2014-10-22
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    [關(guān)鍵詞]
    [摘要]
    目的 對(duì)4-氯-2-氧代-1，2-二氫喹啉-3-甲醛的合成工藝進(jìn)行研究。方法 以苯胺為原料通過酯的氨解、環(huán)合、胺亞甲基化、水解反應(yīng)得到目標(biāo)化合物。結(jié)果 合成了目標(biāo)化合物，并利用MS和1H-NMR確證了結(jié)構(gòu)，此路線所得產(chǎn)品收率為62.1%。結(jié)論 此路線操作簡單，成本低廉，設(shè)計(jì)合理，收率高，適合該化合物的工業(yè)化生產(chǎn)。
    [Key word]
    [Abstract]
    Objective To study the synthetic technology of 4-chloro-2-oxo-1,2-dihydroquinoline-3-carbaldehyde. Methods N1, N3-diphenylmalonamide was used as starting material to synthesize the target compound by ammonolysis of ester, cyclization, methylation of amine, and hydrolysis reaction. Results The target compound was synthesized and characterized by MS and 1H-NMR. The yield of this route was 62.1%. Conclusion The synthetic route for the compound has the advantages of simple operation, low cost, reasonable design, and high yield, which is suitable for the industrial production of the compound.
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