目的 探討前列地爾注射液聯(lián)合尿毒清顆粒治療慢性腎功能不全的臨床療效。方法 2012年7月—2014年2月濟(jì)南市機關(guān)醫(yī)院收治的慢性腎功能不全患者40例，隨機分為治療組（20例）和對照組（20例），對照組在基礎(chǔ)治療上口服尿毒清顆粒1包/次，3次/d。治療組在對照組基礎(chǔ)上靜脈滴注前列地爾注射液10 μg/d，靜滴時間3 h以上。兩組均連續(xù)治療3周。治療后，評價兩組的臨床療效，同時比較兩組治療前后血肌酐（Scr）、內(nèi)生肌酐清除率（Ccr）、尿素氮（BUN）、血紅蛋白（Hb）、血漿白蛋白（Alb）和調(diào)節(jié)性T細(xì)胞（Treg）。結(jié)果 治療組和對照組的總有效率分別為75.0%、65.0%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者BUN、Scr均較治療前顯著降低，Ccr、Hb較治療前顯著升高，同組治療前后差異有統(tǒng)計學(xué)意義（P<0.05，0.01）；且治療后治療組BUN、Scr、Ccr的改善程度優(yōu)于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者CD⁴⁺-Treg、CD⁴⁺CD²⁵⁺CD¹²⁷-Treg均較治療前顯著降低，同組治療前后差異有統(tǒng)計學(xué)意義（P<0.05），且治療組降低程度大于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05，0.01）。兩組患者治療后Th1、Th1/Th2均較治療前顯著增加，Th2顯著降低，同組治療前后差異有統(tǒng)計學(xué)意義（P<0.01）；治療后治療組Th1、Th1/Th2顯著高于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 前列地爾注射液聯(lián)合尿毒清顆粒對慢性腎功能不全具有較好的臨床療效，可通過調(diào)節(jié)患者的免疫功能，改善Th1/Th2水平發(fā)揮作用。

Objective To investigate the effect of Alprostadil Injection combined with Niaoduqing Granules in the treatment of chronic renal insufficiency. Methods Collecting 40 cases suffered from chronic renal insufficiency from July 2012 to February 2014 in the Authority Hospital of Jinan City, which were randomly divided into treatment (20 cases) and control (20 cases) group. Patients in the control group were po administered with Niaoduqing Granules on the basis of foundation treatment, 1 bag/time, three times daily. Patients in the treatment group were iv administered with Alprostadil Injection 10 μg/d for more than 3 h on the basis of control group. The patients in the two groups were treated for 3 weeks. After the treatment, the treatment efficacy was evaluated, while Scr, Ccr, BUN, Hb, Alb, and regulatory T cell were compared between the two groups. Results The efficacies in the treatment and control groups were 75.0% and 65.0%, respectively, and there were differences between the two groups (P < 0.05). After the treatment, BUN and Scr in the two groups were significantly reduced, while the Ccr and Hb were significantly increased, and the difference was statistically significant before and after the treatment in the same group (P < 0.05, 0.01). And after the treatment, BUN, Scr, and Ccr in the treatment group were improved better than those in the control group, and there was significant difference between the two groups (P < 0.05). After the treatment, CD⁴⁺-Treg and CD⁴⁺CD²⁵⁺CD¹²⁷-Treg in the two groups were significantly reduced, and the difference was statistically significant before and after the treatment in the same group (P < 0.05). And reduced degree in the treatment group was greater than that in the control group, and there was significant difference between the two groups (P < 0.05, 0.01). Th1 and Th1/Th2 in the two groups were significantly increased, while Th2 was significantly reduced, and the differenc was statistically significant before and after the treatment in the same group (P < 0.01). After the treatment, Th1 and Th1/Th2 in the treatment group were significantly higher than those in the control group, and there was significant difference between the two groups (P < 0.05). Conclusion Alprostadil Injection combined with Niaoduqing Granules has a good clinical effect in the treatment of chronic renal insufficiency, which maybe through adjust the immune function of patients and improve the levels of Th1/Th2 to play the role.