目的 研究遼寧省腫瘤醫(yī)院藥品不良反應(yīng)（ADR）發(fā)生的特點(diǎn)與一般規(guī)律，為臨床合理用藥提供參考。方法 對遼寧省腫瘤醫(yī)院2011—2013年上報(bào)國家藥品不良反應(yīng)監(jiān)測系統(tǒng)的229例有效ADR報(bào)告進(jìn)行回顧性分析。結(jié)果 229例ADR報(bào)告中，患者性別差異不明顯，年齡主要集中在40～69歲（184例，80.35%），其中50～59歲最多（100例，43.67%）；靜脈滴注給藥最易引發(fā)ADR（328次，91.11%）；引起ADR的藥品主要為抗腫瘤藥物，順鉑為致ADR最多的藥品（63例，27.51%）；血液及造血系統(tǒng)受累居首位（119例，51.97%）。結(jié)論 臨床應(yīng)加強(qiáng)抗腫瘤藥物ADR的監(jiān)測與上報(bào)工作，為合理用藥與患者安全做出保障。

Objective To investigate the characteristics and regularity of adverse drug reaction (ADR) in Liaoning Cancer Hospital and Institute and provide the reference for rational drug use. Methods Effective ADR reports (229 cases) in Liaoning Cancer Hospital and Institute from 2011 to 2013, reported to ADR Monitoring Center of the State, were retrospectively analyzed. Results Among ADR reports (229 cases), the difference between men and women was not obvious, and the cases mainly occurred in the age from 40 to 69 (184 cases, 80.35%), especially from 50 to 59 (100 cases, 43.67%). Iv injection was the most likely way to cause the ADR (328 cases, 91.11%), the largest number of ADR reports was caused by antitumor drugs, the overwhelming majority of ADR was induced by cis-platinum (63 cases, 27.51%). Hematological system involved in ADR was most common (119 cases, 51.97%). Conclusion More attention should be paid on the ADR monitoring and reporting of antitumor drugs to promote clinical rational use and safe medication.