目的 優(yōu)化金蕎麥總黃酮軟膠囊內(nèi)容物的處方.方法 以內(nèi)容物沉降體積比、重新分散性為考察指標(biāo),通過對(duì)基質(zhì)、助懸劑和潤(rùn)濕劑的篩選,確定金蕎麥總黃酮軟膠囊內(nèi)容物的處方.結(jié)果 以大豆油為稀釋劑,金蕎麥總黃酮粉末過120目篩,加大豆油用量為金蕎麥總黃酮1.5倍,單硬脂酸甘油脂1%,司盤80為0.5%,所得金蕎麥總黃酮軟膠囊內(nèi)容物混懸液最為穩(wěn)定.結(jié)論 所得處方合理,制得的金蕎麥總黃酮軟軟膠囊外形分散均勻,軟硬適中,裝量差異符合規(guī)定.

Objective To optimize the prescription of Jinqiaomai Total Favonoids Soft Capsule. Methods Diluent, suspending agent, and moistening agent were screened and sedimentation volume ratio and redispersion were used as indexes to obtain the optimized prescription of Jinqiaomai Total Favonoids Soft Capsule contents. Results Soybean oil was chosen as the diluent and total favonoids powder was passed through 120-mesh sieve. The prescription of Jinqiaomai Total Favonoids Soft Capsule containing soybean oil with 1.5 times amount of total flavonoids, 1% glyceryl monostearate as suspending agent, and 0.5% Span 80 as moistening agent showed the best stability. Conclusion The prescription is reasonable for Jinqiaomai Total Favonoids Soft Capsule with uniform dispersion, moderate hardness, and good content uniformity.