銀屑病是一種復(fù)雜的炎性皮膚疾病,其發(fā)病機(jī)制尚不完全清楚,且反復(fù)發(fā)作,治療難度很大,嚴(yán)重影響了患者的生活和工作,這給新藥研究和篩選帶來(lái)一定的困難.盡管如此,抗銀屑病新藥一直是皮膚病藥物治療學(xué)研究的一個(gè)熱點(diǎn).國(guó)際上在尋找新的抗銀屑病藥物方面一直在做不懈努力,擬用于治療的新候選藥物不斷出現(xiàn),旨在繼續(xù)提高療效和降低毒副作用.目前,可用于治療銀屑病藥物的作用靶點(diǎn)較多,主要集中在核激素受體的配體、免疫信號(hào)轉(zhuǎn)導(dǎo)通路中的相關(guān)細(xì)胞因子和酶,以及作用于表皮的天然藥用藥材.針對(duì)治療銀屑病效果較佳、作用機(jī)制較明確的小分子藥物進(jìn)行總結(jié),為開發(fā)抗銀屑病的新藥提供研究思路.

Psoriasis is a complex and recurrent inflammatory skin disease, its pathogenesis is not entirely clear and the treatment is very difficult, seriously affecting the patient's life and work, which brings some difficulties for research and screening of new drug. Nevertheless, anti-psoriasis drug has been a hot research point of dermatology therapeutics. In the search for new anti-psoriasis drugs, the international researchers have been doing unremitting efforts. The new drug candidates intended for the treatment for psoriasis emerged, aiming to improve the efficacy and reduce the toxicity. At present, there are many targets for the treatment of psoriasis, mainly focusing on the nuclear hormone receptor ligands, cytokines, and enzymes related in immune signal transduction pathway and the natural medicinal herbs acting on the epidermis. This review summarizes the mechanisms of established therapies with emphasis on small molecule drugs with good effects, and provides research ideas for the development of anti-psoriasis new drugs.

天津市科技計(jì)劃項(xiàng)目(13ZCZDSY00100)