白屈菜堿是白屈菜Chelidonium majus的主要活性成分之一,屬于苯并菲啶類生物堿,現(xiàn)作為止痛藥應用于臨床.隨著對白屈菜堿藥理作用的深入研究發(fā)現(xiàn),其具有抗腫瘤、鎮(zhèn)痛、抗菌、解痙等多種藥理作用,且其抗腫瘤作用越來越受到關注.對近年來白屈菜堿藥理作用的國內(nèi)外研究進展做以綜述,為其進一步研究與應用提供理論依據(jù).

Chelidonine, a benzophen anthridine alkaloid, is one of the main effective constituents of Chelidonium majus, which is applied as a painkiller in clinical treatment. The further studies on the pharmacological activities in recent years have demonstrated that chelidonine plays a role in antitumor, analgesic, antibacterial, spasmolysis activities, etc. And the antitumor activity is paid more and more attention. In this paper, research progress on pharmacological activities and mechanisms of chelidonine home and abroad in recent years are reviewed, which could provide a theoretical basis for the further study and application of C. majus.

國家自然科學基金資助項目(81102858);中國博士后科學基金資助項目(2013M531060);黑龍江省自然科學基金資助項目(D200817);黑龍江省博士后科研基金項目(LBH-Z11103);黑龍江省教育廳骨干教師項目(1154G35)