目的 探索黃柏、酒黃柏及鹽黃柏對(duì)熱證大鼠能量代謝的作用規(guī)律.方法 黃柏及其酒和鹽炙品水煎液9.519、1.058 g/kg ig大鼠7 d,測(cè)定生制黃柏對(duì)2,4-二硝基苯酚所致熱證大鼠肛溫,以及血漿中三碘甲腺原氨酸(T₃)、四碘甲腺原氨酸(T₄)、促甲狀腺激素(TSH)、促甲狀腺激素釋放激素(TRH)、肝組織中乳酸脫氫酶(LDH)、琥珀酸脫氫酶(SDH)、肝糖原、Na⁺-K⁺-ATP酶和Ca²⁺-Mg²⁺-ATP酶的含量.結(jié)果 生黃柏、鹽黃柏均可以降低熱證大鼠肛溫,而酒黃柏的作用不明顯.生黃柏、鹽黃柏可以有效降低熱證大鼠的血漿中甲狀腺功能軸(T₃、T₄、TSH、TRH)和肝組織中LDH、SDH、Na⁺-K⁺-ATP酶、Ca²⁺-Mg²⁺-ATP酶的含量,并能增加熱證大鼠肝組織中糖原含量,而酒炙后對(duì)能量代謝指標(biāo)含量作用減弱.結(jié)論 生黃柏能夠改善熱證大鼠的能量代謝,且與甲狀腺途徑有關(guān).鹽炙后寒性增強(qiáng),對(duì)熱證大鼠的能量代謝有進(jìn)一步的改善作用,而酒炙后,緩和黃柏的寒性,對(duì)能量代謝改善效果不顯著.

Objective To explore the effect regularity of raw Phellodendri Cortex and its processed products on energy metabolism in fever rats. Methods After ig administration of water extracts from raw Phellodendri Cortex with doses of 9.519 and 1.058 g/kg for 7 d, rectal temperatures in fever rats caused by subcutaneous 2,4-dinitrophenol were determined. And then the activities of T₃, T₄, TSH, and TRH in plasma and LDH, SDH, Na⁺-K⁺-ATPase, and Ca²⁺-Mg²⁺-ATPase in liver tissue were measured. Results Raw Phellodendri Cortex and Phellodendri Cortex processed by salt could reduce rectal temperature of fever rats, but the effect of Phellodendri Cortex processed by yellow wine had no significant effect. Raw Phellodendri Cortex and Phellodendri Cortex processed by salt could effectively reduce the levels of T₃, T₄, TSH, and TRH in rat plasma and LDH, SDH, Na⁺-K⁺-ATPase, and Ca²⁺-Mg²⁺-ATPase in liver tissue. They could increase the content of glycogen in liver tissue. But the effects of Phellodendri Cortex processed by yellow wine on the contents of energy metabolism indexes were weaker. Conclusion Raw Phellodendri Cortex could improve the energy metabolism of fever rats related to thyroixine pathway. Processing by salt could strengthen these effects, while processing by yellow wine could alleviate the cold property of Phellodendri Cortex without obvious effect on the energy metabolism of fever rats.

國(guó)家自然科學(xué)基金資助項(xiàng)目(81274083)