目的 比較鹽酸伐昔洛韋片和阿昔洛韋注射液治療帶狀皰疹的臨床療效和安全性.方法 選取上海市皮膚病醫(yī)院2012年2月—2014年1月收治的帶狀皰疹患者100例,隨機分為治療組和對照組,每組各50例.治療組口服鹽酸伐昔洛韋片,2片/次,2次/d;對照組靜脈滴注阿昔洛韋注射液加入250 mL 0.9%生理鹽水中,5 mg/kg,2次/d.兩組均連續(xù)治療8 d.觀察并記錄兩組患者的臨床療效和不良反應.結果 治療后,治療組和對照組的總有效率分別為98%、96%,兩組比較差異無統(tǒng)計學意義.兩組患者皮損停止進展時間、開始結痂時間、一半皮疹結痂時間、所有皮疹脫痂時間和開始出現(xiàn)無疼痛時間相比差異無統(tǒng)計學意義.治療組疼痛完全消失時間顯著短于對照組,兩組比較差異有統(tǒng)計學意義(P<0.05).治療組后遺神經痛的發(fā)生率低于對照組,兩組比較差異有統(tǒng)計學意義(P<0.05).結論 鹽酸伐昔洛韋片治療帶狀皰疹具有較好的臨床療效,可以有效縮短疼痛時間,減少后遺神經痛的發(fā)生,值得臨床推廣使用.

Objective To compare the clinical efficacy and safety between Valaciclovir Hydrochloride Tablets and Aciclovir Injection in the treatment of herpes zoster. Methods Herpes zoster patients (100 cases) who came to Shanghai Dermatology Hospitalfrom February 2012 to January 2014 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the treatment group were po administered with Valaciclovir Hydrochloride Tablets, 2 tablets/time, twice daily. The patients in the control group were iv administered with Aciclovir Injection adding into 250 mL of 0.9% saline solution, 5 mg/kg, twice daily. The patients in the two groups were treated for 8 d. The clinical efficacy and adverse reactions in two groups were observed and recorded. Results After treatment, the efficacies in the treatment and control groups were 98% and 96%, respectively, with no difference between the two groups. There was no statistically significant difference between two groups about the time of disease stopping, time of scab beginning, time of half rash scabbing, time of all rash scab off, and time of no pain beginning. The pain disappearing time in the treatment group was significantly shorter than that in the control group, with differences between the two groups (P < 0.05). The incidence of legacy neuralgia in the treatment group was lower than that in the control group, with differences between the two groups (P < 0.05). Conclusion Valaciclovir Hydrochloride Tablets have the good clinical effect in treatment of herpes zoster, and can effectively shorten the pain time and reduce the incidence of legacy neuralgia, which is worth clinical promotion.

國家自然科學基金資助項目(81071304)