目的 運(yùn)用Meta分析方法系統(tǒng)評價(jià)復(fù)方丹參滴丸治療糖尿病腎病(DN)的臨床療效。方法 計(jì)算機(jī)檢索美國醫(yī)學(xué)文摘數(shù)據(jù)庫(Medline)、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(CBM)、中國期刊全文數(shù)據(jù)庫(CNKI)、中文科技期刊全文數(shù)據(jù)庫維普(VIP)和萬方數(shù)字化期刊全文庫等數(shù)據(jù)庫, 對納入的隨機(jī)對照試驗(yàn)文獻(xiàn)進(jìn)行質(zhì)量評價(jià), 并采用Rev Man 5.2軟件進(jìn)行Meta分析。結(jié)局指標(biāo)為尿白蛋白排泄率(UAER)、24 h尿蛋白定量、總膽固醇(TC)和三酰甘油(TG)。結(jié)果 共納入14篇隨機(jī)對照試驗(yàn), 共1 032名患者。Meta分析結(jié)果顯示, 復(fù)方丹參滴丸能顯著減少DN的UAER［MD=-15.76, 95%CI(-17.44, -14.08), P<0.01］、24 h尿蛋白定量［MD=-0.11, 95%CI(-0.12, -0.10)］、TC［MD=-0.80, 95%CI(-1.42, -0.18), P=0.01］和TG［MD=-0.80, 95%CI(-1.42, -0.18), P=0.01］水平。結(jié)論 復(fù)方丹參滴丸能減少DN的尿蛋白和血脂水平;但本研究納入的研究數(shù)量偏少, 且方法學(xué)上存在缺陷, 證據(jù)強(qiáng)度不高, 因此復(fù)方丹參滴丸治療DN的療效仍需深入研究。

Objective To evaluate the clinical efficiency of Compound Danshen Dripping Pills in treatment of diabetic nephropathy by Meta analysis. Methods Using computer searches American medical abstract database (Medline), Chinese biomedical literature database (CBM), China Journal Full-text Database (CNKI), Chinese Science and Technology Journal Full-text Database (VIP), Wanfang Database, etc.And the quality assessment of qualified randomly control trials was evaluated. Meta analysis was carried out by Rev Man 5.2 software. The outcomes included urinary albumin excretion rate (UAER), 24 h urinary protein excretion, total cholesterol (TC), and triglyceride (TG). Results A total of 14 studies were included, involving 1032 patients. Meta analysis showed that Compound Danshen Dripping Pills could significantly decrease in UAER [MD = -15.76, 95%CI (-17.44, -14.08), P < 0.01], 24 h urinary protein excretion [MD = -0.11, 95%CI (-0.12, -0.10)], TC [MD = -0.80, 95%CI (-1.42, -0.18, P = 0.01] and TG [MD = -0.80, 95%CI (-1.42, -0.18, P = 0.01]. Conclusion Compound Danshen Dripping Pills can decrease the urine protein and blood routine. But the poor methodological quality of included studies seriously weaken the validity of the Meta analysis. So the efficacy of Compound Danshen Dripping Pills in treatment of diabetic nephropathy should be deeply studied