目的 觀察坤泰膠囊聯(lián)合枸櫞酸氯米芬膠囊、戊酸雌二醇治療排卵障礙的臨床療效。方法 2013年6月-2014年6月安陽市婦幼保健院收治的排卵障礙患者180例,隨機分為對照組和治療組,每組90例。對照組患者月經第5天口服枸櫞酸氯米芬膠囊,2粒/次,1次/d,共5 d;同時在月經第8天口服戊酸雌二醇片,2片/次,1次/d,直到卵泡成熟。治療組在對照組基礎上從月經第5天開始口服坤泰膠囊,4粒/次,3次/d,直至卵泡成熟。兩組均連續(xù)治療3～6個月,發(fā)現(xiàn)妊娠后停止用藥。結果 治療組成熟卵泡數(shù)目、子宮內膜厚度與對照組比較差異無統(tǒng)計學意義。治療組排卵率和妊娠率均顯著高于對照組,兩組比較差異有統(tǒng)計學意義(P<0.05)。結論 坤泰膠囊聯(lián)合枸櫞酸氯米芬膠囊、戊酸雌二醇治療排卵障礙具有較好的臨床療效,能夠提高排卵率和妊娠率,值得在臨床推廣應用。

Objective To explore the clinical effect of Kuntai Capsules combined with Clomifene Citrate Capsules and estradiol valerate in treatment of ovulation disorder. Methods The patients with ovulation disorder (180 cases) of Anyang Maternal and Child Health Care Centre from June 2013 to June 2014 were randomly divided into control and treatment groups, and each group has 90 cases. The patients in the control group were po administered with Clomifene Citrate Capsules from the fifth day of menstruation for 5 d, 2 capsules/time, once daily. At the same time they were po administered with Estradiol Valerate Tablets from the eighth day of menstruation until follicle was stimulating, 2 tablets/time, once daily. The patients in the treatment group were po administered with Kuntai Capsules from the fifth day of menstruation on the basis of the control group until follicle was stimulating, 4 capsules/time, three times daily. The patients in two groups were treated for 3-6 months until pregnant. Results There was no statistically significant difference between two groups about mature follicles number and endometrial thickness. The ovulation rate and pregnancy rate in the treatment group were higher than those in the control group, and there were differences between two groups (P< 0.05). Conclusions Kuntai Capsules combined with Clomifene Citrate Capsules and estradiol valerate have the good clinical effect in treatment of ovulation disorder, and can increase ovulation rate and pregnancy rate, which is worth clinical promotion.